Dr. Daniela Pellegrino
Journal of Clinical and Medical Science
Biology, Ecology and Earth Sciences
Name: Dr. Daniela Pellegrino
Educational Qualification: M.D. Ph.D. Post-Doc.
Designation: Assistant Professor at University of Calabria, Italy.
Department: Biology, Ecology and Earth Sciences
University: University of Vancouver
Email: anielapellegrino@unical.it
Research Interests: 1. Oxidative stress, aging and chronic kidney disease (CKD): traditional and/or specific risk factors for chronic renal failure (oxidative stress, inflammation, endothelial damage) in both patients (CKD or end stage renal disease) and animal model (rat). In collaboration with "Kidney and Transplantation" Research Centre, Annunziata Hospital. 2. Oxidative stress as a new cardiovascular risk factor: epidemiological studies and animal models (spontaneously hypertensive rats and obese rats). 3. Morphofunctional cardiovascular adaptations to extreme environments: physiological relevance of nitric oxide signalling in the control of cardiac performance in both mammalian (rat) and non-mammalian (Antarctic and temperate teleost) experimental models. Italian National Research Program in Antarctica.
Biography: Education and Training 2000-2003 Research fellowship Department of Cellular Biology , UNICAL; Institute for fiskeri-og marinbiologi HØYTEKNOLOGI-SENTERET, University of Bergen, Norway; Institute for Polar and Marine Research “Alfred Wegener”, Bremerhaven, Germany. 1998-2000 Post-Doc research fellowship Department of Cellular Biology , UNICAL; Zoological Laboratory, University of Vancouver, Canada; Bamfield Marine Sciences Centre, Vancouver Island, Canada. 1994-1996 PhD in Animal Biology Department of Cellular Biology , UNICAL; Zoological Laboratory, University of Vancouver, Canada; Zoological Station "A. Dohrn “, Naples, Italy. Experimental thesis: Effects of nitric oxide on fish gill and frog heart. Scientific field Physiology 1994 Qualification as a Professional Biologist UNICAL 1993-1994 Research fellowship Research within the CEE n. AIR1-CT920186 project “Improvement of the nutritional value, growth and resistance to stress of eels and sturgeon by controlled dietary lipids and conditions during intensive aquaculture". UNICAL, University of Birmingham, University of Copenhagen. 1993 Master’s degree in Biology Department of Cellular Biology , UNICAL. Experimental thesis: Effects of the endothelin on the isolated and perfused frog heart. Scientific field Physiology
Profiles
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- E. Brunelli, D. La Russa, D. Pellegrino. Impaired oxidative status is strongly associated with cardiovascular risk factors. Oxid Med Cell Longev, in press (2017).
- D. La Russa, E. Brunelli, D. Pellegrino. Oxidative imbalance and kidney damage in spontaneously hypertensive rats: activation of extrinsic apoptotic pathway. Clin Sci (Lond), 131(13): 1419-1428 (2017).
- R. Macirella, A. Guardia, D. Pellegrino, I. Bernabò, V. Tronci, L.O.E. Ebbesson, S. Sesti, S. Tripepi, E. Brunelli. “Effects of two sublethal concentrations of mercury chloride on the morphology and metallothionein activity in the liver of zebrafish (Danio rerio). Int J Mol Sci, 17, 361 (2016).
- D. Pellegrino. “Antioxidants and Cardiovascular Risk Factors”. Diseases, 4, 11 (2016).
- E. Brunelli, A. Ferraro, R. Macirella, D. Pellegrino, F. Romeo, M.L. Panno. “AR and CgA in situ detection as prognostic clinical markers in prostate adenocarcinoma”. IJLRST, 4(6): 39-43 (2015).
- F. Garofalo, D. Amelio, A. Gattuso, M.C. Cerra, D. Pellegrino. “Cardiac contractility in Antarctic teleost is modulated by nitrite through xanthine oxidase and cytochrome p-450 nitrite reductase”. Nitric Oxide-Biology and Chemistry, 49:1-7 (2015).
- E. Brunelli, F. Domanico, D. La Russa, D. Pellegrino. “Sex differences in circulating oxidative stress biomarkers”. Current Drug Targets 15(8): 811-815 (2014).
- G. Montesanti, M.L. Parisella, G. Garofalo, D. Pellegrino. “Nitrite as Direct S-Nitrosylating Agent of Kir2. 1 Channels” International Scholarly Research Notices ID 517126 (2014).
- T. Angelone, E. Filice, A. Quintieri, S. Imbrogno, N. Amodio, T. Pasqua, D. Pellegrino, F. Mulè, MC. Cerra. “Receptor indentification and physiological characterization of glucagon-like peptide-2 in the rat heart”. Nutrition Metabolism and Cardiovascular Diseases, 22(6): 486-494 (2012).
- ML. Parisella, T. Angelone, A. Gattuso, MC. Cerra, D. Pellegrino. “Glycyrrhizin and glycyrrhetinic acid directly modulate cardiac performance in rat beating hearts”. Journal of Nutritional Biochemistry, 23(1): 69-75 (2012).
- E. Filice, T. Angelone, EM. De Francesco, D. Pellegrino, M. Maggiolini, MC. Cerra. “Crucial role of phospholamban phosphorylation and S-nitrosylation in the negative lusitropism induced by 17β-estradiol in the male rat heart”. Cell Physiol Biochem., 28(1): 41-52 (2011).
- D. Pellegrino, M.L. Parisella. “Nitrite as a Physiological Source of Nitric Oxide and a Signalling Molecule in the Regulation of the Cardiovascular System in Both Mammalian and Non-Mammalian Vertebrates”. Recent Pat Cardiovasc Drug Discov., 5(2): 91-96 (2010).
- E. Filice, A.G. Recchia, D. Pellegrino, T. Angelone, M. Maggiolini, M.C. Cerra. “A new membrane G protein-coupled receptor (GPR30) is involved in the cardiac effects of 17beta-estradiol in the male rat”. J. Physiol. Pharmacol., 60 (4): 3-10 (2009).
- F. Garofalo, D. Pellegrino, D. Amelio, B. Tota. “The Antarctic hemoglobinless icefish, fifty five years later: A unique cardiocirculatory interplay of disaptation and phenotypic plasticity”. Comp. Biochem. Physiol., 154A: 10-28 (2009).
- M.C. Cerra, T. Angelone, M.L. Parisella, D. Pellegrino and B. Tota. “Nitrite modulates contractility of teleost (Anguilla anguilla and Chionodraco hamatus, i.e. the Antarctic hemoglobinless icefish) and frog (Rana esculenta) hearts”. BBA, 1787:849–855 (2009).
- D. Pellegrino, S. Shiva, T. Angelone, M.T. Gladwin and B. Tota. “Nitrite exerts potent negative inotropy in the isolated heart via eNOS-independent nitric oxide generation, cGMP-PKG pathway activation and inhibition of mitochondrial respiration”. BBA, 1787:818–827 (2009).
- L. Quassinti, D. Pellegrino, F. Garofalo, E. Maccari, M. Bramucci. "Comparison of angiotensin converting enzyme-like activity in the Antarctic teleosts Trematomus bernacchii and Chionodraco hamatus”. Polar Biology, 32:673–677 (2009).
- A.G. Recchia, E. Filice, D. Pellegrino, A. Dobrinaa, M.C. Cerra, M. Maggiolini. “Endothelin-1 induces Connective Tissue Growth Factor expression in cardiomyocytes”. JMCC, 46(3):352-359 (2009).
- F. Garofalo, D. Amelio, M.C. Cerra, B. Tota, B.D. Sidell and D. Pellegrino. “Morphological and Physiological study of the Cardiac NOS-NO System in the Antarctic (Hb-/Mb-) icefish Chaenocephalus aceratus and in the red-blooded Trematomus bernacchii”. Nitric Oxide-Biology and Chemistry, 20: 69-78 (2009).
- T. Angelone, E. Filice, A. Quintieri, S. Imbrogno, E. Pulera', C. Mannarino, D. Pellegrino and M.C. Cerra. " Beta3-adrenoceptors modulate left ventricular relaxation in the rat heart via the NO-cGMP-PKG pathway". Acta Physiol (Oxf), 193(3): 229-239 (2008).
- M.C. Cerra and D. Pellegrino. "Cardiovascular cGMP-generating systems in physiological and pathological conditions". Current Medicinal Chemistry, 14(5): 585-599 (2007).
- D. Amelio, F. Garofalo, D. Pellegrino, F. Giordano, B. Tota and M.C. Cerra. “Cardiac expression and distribution of Nitric Oxide Synthases in the ventricle of the cold-adapted Antarctic teleosts, the hemoglobinless Chionodraco hamatus and the red-blooded Trematomus bernacchii ”. Nitric Oxide-Biology and Chemistry, 15(3): 190-198 (2006).
- B. Tota, D. Amelio, D. Pellegrino, Y.K. Ip and M.C. Cerra. “NO modulation of myocardial performance in fish hearts”. Comp. Biochem. Physiol. (A), 142(2): 164-177 (2005).
- D. Pellegrino, B. Tota and D.J. Randall. “Adenosine/Nitric oxide cross-talk in the branchial circulation of Squalus acanthias and Anguilla anguilla”. Comp. Biochem. Physiol. (A), 142(2): 198-204 (2005).
- D. Pellegrino, R. Acierno and B. Tota. “Control of cardiovascular function in the icefish Chionodraco hamatus: involvement of serotonin and nitric oxide”. Comp. Biochem. Physiol. (A) 134(2): 471-480 (2003).
- D. Pellegrino, C.A. Palmerini and B. Tota. “No hemoglobin but NO: the icefish (Chionodraco hamatus) heart as a paradigm”. J. Exp. Biol. 207(22): 3855-3864 (2004).
- D. Pellegrino, E. Sprovieri, R. Mazza, D.J. Randall and B. Tota. “Nitric oxide-cGMP-mediated vasoconstriction and effects of acetylcholine in the branchial circulation of the eel” Comp. Biochem. Physiol. (A)132: 447-457 (2002).
- M. Maffia, R. Acierno, M. Rollo, A. Rizzello, C. Storelli, D. Pellegrino and B. Tota. “Ionic regulation in Antarctic teleosts”. Ital. J. Zool., supplement 1: 47-52 (2000).
- C. Agnisola, D.J. McKenzie, D. Pellegrino, P. Bronzi, B. Tota, E.W. Taylor. “Cardiovascular response to hypoxia in the Adriatic sturgeon (Acipenser naccarii)”. J. Appl. Ichthyol. 15: 67-72 (1999).
- Gattuso, D. Pellegrino, R. Mazza and B. Tota. "Endocardial endothelium mediates luminal ACh-NO signaling in isolated frog heart". Am. J. Physiol. 276:H633-H641 (1999).
- Tota, M.C. Cerra, R. Mazza, D. Pellegrino and J. Icardo, "The heart of the Antarctic icefish as paradigm of cold adaptation". J. Thermal Biol. 22(6):409-417 (1997).
- S.U. Sys, D. Pellegrino, R. Mazza, A. Gattuso, L.J. Andries and B. Tota. "Endocardial endothelium in the avascular heart of the frog: morphology and role of nitric oxide". J. Exp. Biol. 200: 3109-3118 (1997).
- R. Acierno, A. Gattuso, M.C. Cerra, D. Pellegrino, C. Agnisola and B. Tota. "The isolated and perfused working heart of the frog, Rana esculenta: an improved preparation". General Pharmacology 25(3): 521-526 (1994).
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