Dr. Jens Gruber

Journal of Drug Development and Delivery

Molecular Biology

Name: Dr. Jens Gruber

Educational Qualification: Ph.D.

Designation: Head Junior Researcher for Medical RNA Biology at German Primate Center, Germany

Department: Molecular Biology

University: Leibniz Institute for Primate Research

Email: jens.gruber@gmail.com

Research Interests: Molecular Biology; Medical RNA Biology; Biology; Biophysical Chemistry; Applied Bioinformatics; functional Genomics; directed delivery; lentiviral and non-viral gene delivery; small RNA analyses; biotechnology

Biography: Currently he is working as a Head Junior Researcher for Medical RNA Biology at German Primate Center, Leibniz Institute for Primate Research, Germany and also a member of the Technology Platform “Neuro-Optogenetics”. He worked as a Scientist at the German Primate Center, Primate Genetics Laboratory (Focus on non-protein-coding RNA during viral infections), at the Academic Medical Center oft he University of Amsterdam (Netherlands) and the Max-Planck Institute for Biophysical Chemistry (Göttingen, Germany). He is a Co-Founder of VD2Tec GmbH, Göttingen, Germany. Jens is concentrating on solutions for directed gene delivery in viral and non-viral vectors and functional analysis of non-protein coding RNAs.

Gruber J, Harborth J, Schnabel J, Weber K, Hatzfeld M. The mitotic-spindle-associated protein astrin is essential for progression through mitosis. J Cell Sci. 2002; 115: 4053-9.
Gruber J, Boese G, Tuschl T, Osborn M, Weber K. RNA interference by osmotic lysis of pinosomes: liposome-independent transfection of siRNAs into mammalian cells. Biotechniques. 2004; 37: 96-102.
Gruber J, Lampe T, Osborn M and Weber K RNAi of FACE1 protease results in growth inhibition of human cells expressing lamin A; implications for Hutchinson-Gilford Progeria Syndrome. J Cell Science 2005; 118: 689-96.
Gruber J, Manninga H, Tuschl T, Osborn M and Weber K Specific RNAi mediated gene knockdown in zebrafish cell lines. RNA Biol. 2005 Jul 19;2(3) (IF 1.12)
Hossbach M*, Gruber J*, Osborn M, Weber K, Tuschl T. Gene silencing with siRNA duplexes composed of target-mRNA-complementary and partially palindromic or partially complementary single-stranded siRNAs. RNA Biol. 2006 Apr;3(2):82-9.
Liu YP, Gruber J, Haasnoot J, Konstantinova P, and Berkhout B (2009) RNAi-mediated inhibition of HIV-1 by targeting partially complementary viral sequences, Nucleic Acids Res 37, 6194-6204.
Brameier M, Herwig A, Reinhardt R, Walter L, Gruber J (2010): Human C/D box snoRNAs with miRNA-like functions: Expanding the range of regulatory RNAs. Nucleic Acids Res 2011, 39(2):675-86.
Gruber, J. (2005) Functional gene analysis in cultured vertebrate cells using siRNA mediated gene silencing, PhD Thesis University of Göttingen, Max-Planck International Research School “Molecular Biology”
Jens Gruber, Wei Cun See Too, Mun Teng Wong, Arnon Lavie, Theresa McSorley and Manfred Konrad (2012): Balance of Human Choline Kinase Isoforms is Critical for Cell Cycle Regulation: Implications for the development of choline kinase-targeted cancer therapy. FEBS J. 2012 Jun;279(11):1915-28
Hoffmann DB a, Boker KO, Schneider S, Eckermann-Felkl E, Schuder A, Komrakova M, Sehmisch S, Gruber J. In Vivo siRNA Delivery Using JC Virus-like Particles Decreases the Expression of RANKL in Rats. Mol Ther Nucleic Acids 2016; 5: e298
Azadeh Azizian, Jens Gruber, Michael B. Ghadimi, Jochen Gaedcke; MicroRNA in rectal cancer World J Gastrointest Oncol. 2016 May 15;8(5):416-26.
Stefan Pöhlmann, Astrid Krüger, Wali Hafezi, Stefan Schneider, Jens Gruber, Michael Winkler, and Artur Kaul. Detection systems for antibody responses against herpes B virus. Primate Biol., 4, 9-16, 2017.
Lemus-Diaz N, Böker KO, Rodriguez-Polo I, Mitter M, Preis J, Gruber J. Dissecting the gene regulatory activity of miRNAs at the single cell level. Sci. Rep.7, 45197; doi:10.1038/srep45197 (2017)
Pawel Zmora, Paulina Molau-Blazejewska, Stephanie Bertram, Kerstin Walendy-Gnirß, Inga Nehlmeier, Anika Hartleib, Anna-Sophie Moldenhauer, Sebastian Konzok, Susann Dehmel, Katharina Sewald, Constantin Brinkmann, Christoph Curths, Sascha Knauf, Jens Gruber, Kerstin Mätz-Rensing, Franziska Dahlmann, Armin Braun, Stefan Pöhlmann. Non-human primate orthologues of TMPRSS2 cleave and activate the influenza virus hemagglutinin. PLOS ONE, 2017
Peter Jo 1, Azadeh Azizian 1, Junius Salendo 1, Frank Kramer 2, Markus Bernhardt 1, Hendrik A. Wolff 3, Jens Gruber 4, Marian Grade 1, Tim Beißbarth 2, B. Michael Ghadimi 1, Jochen Gaedcke. Changes of Microrna Levels in Plasma of Patients with Rectal Cancer during Chemoradiotherapy. IJMS, 2017

Serial no:IIEBM0238

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Dr. Jens Gruber

Journal of Drug Development and Delivery

Molecular Biology

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